27 articles - From Friday Nov 04 2022 to Friday Nov 11 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases. These recommendations provide guidance on the screening and prevention of chronic and opportunistic infections. Their adoption in clinical practice is recommended to standardise and optimise care to reduce the burden of opportunistic infections in people living with AIIRD. |
| Arthritis Care Res (Hoboken) |
A Narrowing Mortality Gap: Temporal Trends of Cause-Specific Mortality in a National, Matched Cohort Study in U.S. Veterans with Rheumatoid Arthritis. Excess RA-related mortality was driven by cardiovascular, cancer, respiratory, and infectious causes, particularly cardiopulmonary diseases. Though our findings support that RA-related mortality risk is decreasing over time, a mortality gap remains for all-cause and cause-specific mortality in RA. |
Association of change in BMI with incidence and progression of the structural defects of hip osteoarthritis: data from the OAI and CHECK studies. Weight loss may not be an effective strategy for preventing, slowing or delaying the structural defects of hip osteoarthritis over 4 to 5 |
Impact of the COVID-19 Pandemic on Early Career Investigators in Rheumatology: Recommendations to Address Challenges to Early Research Careers. Major identified stressors during the pandemic included increased caregiving responsibilities and difficulty obtaining data and funding for which respondents suggested increases and changes to funding programs as well as more mentoring and networking opportunities. Based on these, the Committee on Research proposes three priorities (1) flexible funding mechanisms for ECIs and additional support for those impacted by caregiving; (2) virtual and in person programs for career development and networking; (3) curated content relevant to building a research career available on-demand. |
The Association of Hydroxychloroquine Dosing with Adverse Cardiac Events in Patients with Systemic Lupus Erythematosus. Higher HCQ doses were not associated with an increased risk of HFrEF, life-threatening arrhythmia or cardiac death among patients with SLE and may decrease the risk among non-smokers. |
| Arthritis Res Ther |
Macrophage polarization toward M1 phenotype through NF- BD serum promoted macrophage polarization toward a proinflammatory M1-like phenotype through NF- |
| Arthritis Rheumatol |
American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 5. These guidance statements are intended to provide direction to rheumatology health care providers on how to best use COVID-19 vaccines and to facilitate implementation of vaccination strategies for RMD patients. |
| Rheumatology (Oxford) |
CCL24, CXCL9, and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment. In patients with oligoarticular JIA, regardless of disease onset and progression, the consistent elevation of any or al three markers, the CCL24, CXCL9, and CXCL10 in synovial fluids was associated with the future use of advanced therapy which could be reflective of disease severity. |
Impact of pregnancy on progression of preclinical autoimmune disorders: a prospective cohort study. Among women with suspected autoimmune disease during pregnancy, additional viable pregnancies and diagnosis of preeclampsia were independently associated with an increased rate of progression to definite rheumatic disorder. Hormonal modifications associated with pregnancy could worse preclinical rheumatic disorders favouring their progression to a defined autoimmune disease. |
Improving outcomes in scleroderma: recent progress of cell-based therapies. Novel cell therapies-such as mesenchymal stem cells, chimeric antigen receptor-based therapy, tolerogenic dendritic cells, and facilitating cells-that may restore self-tolerance with more favourable safety and tolerability profiles are being explored for the treatment of dcSSc and other autoimmune diseases. This narrative review examines these evolving cell therapies. |
Preclinical ocular changes in systemic lupus erythematosus patients by optical coherence tomography. SD-OCT and OCTA can detect preclinical structural and microcirculatory changes in SLE patients. Structural and perifoveal vascular macular changes in SLE patients are related with disease duration. Macular structural parameters were impaired in patients with higher disease damage. Antiphospholipid syndrome seems to be associated with preclinical damage of the optic nerve and impairment of the perifoveal microvasculature. |
Treat-to-target urate-lowering therapy and hospitalisations for gout: results from a nationwide cohort study in England. ULT associates with an increased risk of hospitalisations within the first 6 |
Type I interferon and neutrophil transcripts in lupus nephritis renal biopsies: Clinical and histopathological associations. IFN-I transcripts are expressed locally in kidneys from patients with proliferative lupus nephritis and associated with impaired renal function. Elevated defensin-a3 transcripts, a neutrophil product associated with neutrophil extracellular traps, may identify a driver of local IFN-I expression. These findings provide insight into the mechanisms of proliferative lupus nephritis and may inform therapeutic decisions regarding selection of IFN-I pathway inhibitors. |
Vision transformer assisting rheumatologists in screening for capillaroscopy changes in systemic sclerosis: an artificial intelligence model. The ViT is a modern, well-performing and readily available tool for assessing patterns of microangiopathy on NFC images, and it may assist rheumatologists in generating consistent and high-quality NFC reports; however, the final diagnosis of a scleroderma pattern in any individual case needs the judgement of an experienced observer. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Care Res (Hoboken) |
Patient and physician global assessments of disease status in systemic sclerosis. These instruments were not developed using rigorous methodology and have not been fully validated. There is a pressing need for standardisation and validation of patient and physician global assessment tools in SSc to enable universal application of these measures to across RCTs in SSc. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Rheumatology (Oxford) |